How is Methyl (3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoate (CAS: 881995-69-3) typically synthesized?

Methyl (3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoate (CAS: 881995-69-3) is typically synthesized via a multi-step process involving the bromination of 2,4,5-trifluorobenzyl alcohol, followed by nucleophilic substitution with methylamine. This process utilizes a phase transfer catalyst and occurs in polar aprotic solvents. The yield is generally moderate to good, and the selectivity is high due to the steric strain in the 3r configuration.