Compound Q&A

How is 2,3-Difluoro-4-methoxybenzonitrile (CAS: 256417-12-6) typically synthesized?

Answer

2,3-Difluoro-4-methoxybenzonitrile
2,3-Difluoro-4-methoxybenzonitrile is commonly synthesized via the reaction of 4-methoxybenzonitrile with fluorine gas under anhydrous conditions, catalyzed by a suitable fluorinating agent such as tetrafluoroethylene. The process provides good yield and selectivity for the desired product. Other methods include the use of direct fluorination or sequential fluorination and methoxylation reactions.

About

English Name 2,3-Difluoro-4-methoxybenzonitrile
Molecular Formula C8H5F2NO
Molecular Weight 158.15 g/mol
SMILES COC1=C(C(=C(C=C1)C#N)F)F
InChIKey WCUIDHSEDJPJKI-UHFFFAOYSA-N
Last Updated: 2025-11-04 13:04

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