How is methyl 5-amino-2-bromo-4-methylbenzoate (CAS: 474330-54-6) typically synthesized?

Methyl 5-amino-2-bromo-4-methylbenzoate is typically synthesized through a multi-step process involving the bromination of 4-methylbenzoic acid, followed by the acylation with methylamine. Commonly, N-bromosuccinimide (NBS) is used as a brominating agent, and the acylation step employs a mild base like triethylamine. The overall reaction provides a yield of approximately 85% and is carried out under mild conditions to ensure selectivity.