Compound Q&A

How is 5-Fluoro-1-benzothiophene (CAS: 70060-12-7) typically synthesized?

Answer

5-Fluoro-1-benzothiophene
5-Fluoro-1-benzothiophene can be synthesized via the halo substitution of 1-benzothiophene with hydrogen fluoride (HF) in the presence of a suitable catalyst such as iron trifluoromethanesulfonate. The reaction conditions typically involve heating the mixture to 100°C under an inert atmosphere. This method provides good yield and selectivity for the substitution product.

About

CAS No 70060-12-7
English Name 5-Fluoro-1-benzothiophene
Molecular Formula C8H5FS
Molecular Weight 152.19 g/mol
SMILES C1=CC2=C(C=CS2)C=C1F
InChIKey VKBPSLNJNKFVAC-UHFFFAOYSA-N
Last Updated: 2025-11-04 13:04

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