Compound Q&A

How is Ethyl 2-amino-5-chloronicotinate (CAS: 169495-51-6) typically synthesized?

Answer

Ethyl 2-amino-5-chloronicotinate
Ethyl 2-amino-5-chloronicotinate (CAS: 169495-51-6) is typically synthesized by the reaction of nicotinic acid with ethylamine in the presence of a catalyst such as anhydrous aluminum chloride. The reaction yields a mixture that is purified by recrystallization. The process involves the introduction of an amino group and a chlorine atom to the nicotinic acid structure.

About

English Name Ethyl 2-amino-5-chloronicotinate
Molecular Formula C8H9ClN2O2
Molecular Weight 200.63 g/mol
SMILES CCOC(=O)c1cc(Cl)cnc1N
InChIKey QFAFZWZBZJZCKN-UHFFFAOYSA-N
Last Updated: 2025-11-04 13:04

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