Compound Q&A
How is 2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS: 16867-35-9) typically synthesized?
Answer
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2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one is typically synthesized via a nucleophilic substitution reaction of pyridopyrimidine-4(3H)-one with chloromethyl chlorides. The reaction is catalyzed by a Lewis acid such as aluminum trichloride. The yield is generally high, and the compound can be isolated by recrystallization from organic solvents. This synthesis method ensures good selectivity and high purity of the product.
About
CAS No
16867-35-9
English Name
2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
Molecular Formula
C9H7ClN2O
Molecular Weight
194.62 g/mol
SMILES
C1=CC2=NC(=CC(=O)N2C=C1)CCl
InChIKey
QANDFEYEAYUSKD-UHFFFAOYSA-N
Last Updated: 2025-11-01 22:12
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