Compound Q&A
How is 5-Bromo-6-methyl-1H-benzimidazole (CAS: 116106-16-2) typically synthesized?
Answer
5-Bromo-6-methyl-1H-benzimidazole can be synthesized via bromination of 6-methyl-1H-benzimidazole using N-bromosuccinimide (NBS) in the presence of a radical initiator, such as benzoyl peroxide. The reaction is typically conducted in an inert atmosphere to prevent oxidation. The yield is generally around 70-80%, and the product can be purified by recrystallization from ethanol or methanol.
About
CAS No
116106-16-2
English Name
5-Bromo-6-methyl-1H-benzimidazole
Molecular Formula
C8H7BrN2
Molecular Weight
211.06 g/mol
SMILES
Cc1cc2c(cc1Br)[nH]cn2
InChIKey
ZQHHVSZEBVWTRO-UHFFFAOYSA-N
Last Updated: 2025-11-01 22:12
