Compound Q&A
How is N-[(1-Cyanocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide (CAS: 2097381-85-4) typically synthesized?
Answer
![N-[(1-Cyanocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide](https://static.chemtradehub.com/structs/209/2097381-85-4-5b40.webp "N-[(1-Cyanocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide")
N-[(1-Cyanocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide is synthesized via a multi-step process involving acylation, amidation, and alkylation reactions. The process typically requires protected precursors, careful control of reaction conditions, and the use of catalysts like titanium(IV) isopropoxide. The overall yield is around 60-70%, with excellent selectivity to the desired product.
About
CAS No
2097381-85-4
English Name
N-[(1-Cyanocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65 g/mol
SMILES
Cc1c(scn1)c2ccc(cc2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O
InChIKey
NDVQUNZCNAMROD-RZUBCFFCSA-N
Last Updated: 2025-11-01 22:12
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