How is (2S,3R)-3-(tert-butoxy)-2-acetamidobutanoic acid (CAS: 163277-80-3) typically synthesized?

(2S,3R)-3-(tert-butoxy)-2-acetamidobutanoic acid is typically synthesized via a multi-step process involving the protection of the carboxylic acid group, followed by acetylation and amidation. Common reagents include tert-butyldimethylsilyl chloride and acetic anhydride, with catalytic amounts of a suitable base such as imidazole. The reaction conditions are optimized to achieve high yield and selectivity, often requiring the use of a stirring apparatus and a temperature-controlled environment.