Compound Q&A
How is N-[(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hydroxyacetamide] (CAS: 1599440-33-1) typically synthesized?
Answer
![N-[(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxyacetamide](https://static.chemtradehub.com/structs/159/1599440-33-1-411b.webp "N-[(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxyacetamide")
This compound is typically synthesized through a multistep process involving the formation of a key intermediate, followed by dehydration and amide formation. Commonly used catalysts include organometallic reagents and acid or base catalysts. The synthesis involves protecting groups to control reactivity and ensure selectivity, leading to high yields of the desired product.
About
CAS No
1599440-33-1
English Name
N-[(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxyacetamide
Molecular Formula
C26H24FN3O6
Molecular Weight
493.49 g/mol
SMILES
CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5cc(c(c6c5c4[C@H](CC6)NC(=O)CO)C)F)O
InChIKey
PLXLYXLUCNZSAA-QLXKLKPCSA-N
Last Updated: 2025-11-01 12:59
![N-[(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxyacetamide — ShangHaiMaiRuiErShengHua Technology Co Ltd](https://static.chemtradehub.com/suppliers/67ced3b52b2de6e8e95a6e52/67ced3b52b2de6e8e95a6e52-logo.webp){kind=logo}
![N-[(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxyacetamide — ShenZhenZhenJiangShengWuJiShu Co Ltd](https://static.chemtradehub.com/suppliers/67cec9142b2de6e8e95a51e7/67cec9142b2de6e8e95a51e7-logo.webp){kind=logo}
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![N-[(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxyacetamide — ShangHaiJiZhiShengHua Technology Co Ltd](https://static.chemtradehub.com/suppliers/67cecbee2b2de6e8e95a5b72/67cecbee2b2de6e8e95a5b72-logo.webp){kind=logo}
![N-[(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxyacetamide — Shanghai Yinxin Laboratory Equipment Co., Ltd.](https://static.chemtradehub.com/suppliers/67cdd97a57537e5c8069adfb/67cdd97a57537e5c8069adfb-logo.webp){kind=logo}