Compound Q&A
How is 1-(3-Nitrophenyl)piperazine (CAS: 54054-85-2) typically synthesized?
Answer
1-(3-Nitrophenyl)piperazine can be synthesized via a multistep procedure starting from piperazine and 3-nitrobenzaldehyde. The synthesis involves the formation of an intermediate Schiff base, followed by an intramolecular cyclization step. Commonly, this reaction is catalyzed by pivalic acid, leading to a high yield. The overall reaction is selective and efficient, making it a suitable method for the large-scale production of this compound.
About
CAS No
54054-85-2
English Name
1-(3-Nitrophenyl)piperazine
Molecular Formula
C10H13N3O2
Molecular Weight
207.23 g/mol
SMILES
C1CN(CCN1)C2=CC(=CC=C2)[N+](=O)[O-]
InChIKey
LHHZRIYUOZPKSG-UHFFFAOYSA-N
Last Updated: 2025-11-01 12:59
