Compound Q&A

How is (+)-1,4-Di-O-benzyl-D-threitol (CAS: 91604-41-0) typically synthesized?

Answer

(+)-1,4-Di-O-benzyl-D-threitol
The (R)-enantiomer of (+)-1,4-Di-O-benzyl-D-threitol (CAS: 91604-41-0) can be synthesized via a stereoselective reaction of D-threitol with benzyl chloride in the presence of a Lewis acid catalyst. The reaction yields a high enantiomeric excess, typically greater than 99%, with good yield. This method is commonly used in the preparation of optically active compounds for pharmaceutical and biochemical applications.

About

CAS No 91604-41-0
English Name (+)-1,4-Di-O-benzyl-D-threitol
Molecular Formula C18H22O4
Molecular Weight 302.4 g/mol
SMILES C1=CC=C(C=C1)COCC(C(COCC2=CC=CC=C2)O)O
InChIKey YAVAVQDYJARRAU-QZTJIDSGSA-N
Last Updated: 2025-10-31 20:53

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