Compound Q&A

How is 2-Azaspiro[4.5]decan-1-one (CAS: 1005-85-2) typically synthesized?

Answer

2-Azaspiro[4.5]decan-1-one
2-Azaspiro[4.5]decan-1-one (CAS: 1005-85-2) is typically synthesized via a condensation reaction of an appropriately substituted acetaldehyde with a cyclic amine. Common methods involve the use of a Lewis acid catalyst, such as aluminum chloride, to promote the condensation. The yield can be up to 80%, with good selectivity for the azaspiro product.

About

CAS No 1005-85-2
English Name 2-Azaspiro[4.5]decan-1-one
Molecular Formula C9H15NO
Molecular Weight 153.23 g/mol
SMILES O=C1NCCC21CCCCC2
InChIKey UYZFAPXBVNFJFD-UHFFFAOYSA-N
Last Updated: 2025-10-31 17:33

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