Are there alternatives to Clavulanic acid impurity F (CAS: 1260857-16-6) in synthesis?

In the synthesis of clavulanic acid, alternative impurities like Clavulanic acid impurity G and H are sometimes used as they can serve similar functional roles. However, it is crucial to evaluate these alternatives for their safety, efficacy, and regulatory compliance. Common substitute reagents include acetic acid and sodium hydroxide, which are well-regulated and readily available.