Compound Q&A

How is 4-Chloro-2-(chloromethyl)-3-methylpyridine hydrochloride (CAS: 152402-97-6) typically synthesized?

Answer

4-Chloro-2-(chloromethyl)-3-methylpyridine hydrochloride (1:1)
4-Chloro-2-(chloromethyl)-3-methylpyridine hydrochloride (CAS: 152402-97-6) is typically synthesized via the reaction of 3-methylpyridine with chloromethyl chloride in the presence of a base such as sodium carbonate. The reaction is carried out in an aqueous medium, and the hydrochloride salt is formed, which is then crystallized from the reaction mixture. This method provides good selectivity and yield.

About

English Name 4-Chloro-2-(chloromethyl)-3-methylpyridine hydrochloride (1:1)
Molecular Formula C7H8Cl3N
Molecular Weight 212.507 g/mol
SMILES CC1=C(C=CN=C1CCl)Cl.Cl
InChIKey YIDBERCXNYKRKU-UHFFFAOYSA-N
Last Updated: 2025-10-29 13:16

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