Compound Q&A

How is Methyl (3-amino-2,6-difluorophenyl)acetate (CAS: 361336-80-3) typically synthesized?

Answer

Methyl (3-amino-2,6-difluorophenyl)acetate
Methyl (3-amino-2,6-difluorophenyl)acetate is synthesized via a multi-step process involving the reduction of a precursor diazonium salt followed by the coupling reaction with a methyl ester. Commonly used catalysts include palladium-based complexes. The reaction typically yields a high selectivity towards the desired product with a yield of around 75-85%. Care must be taken to use appropriate safety equipment and handle the intermediate diazonium salt under inert conditions to prevent unwanted reactions.

About

English Name Methyl (3-amino-2,6-difluorophenyl)acetate
Molecular Formula C9H9F2NO2
Molecular Weight 201.17199999999997 g/mol
SMILES COC(=O)CC1=C(C=CC(=C1F)N)F
InChIKey ROSSYYRWJGVZJB-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15

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