Compound Q&A
How is 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (CAS: 54240-36-7) typically synthesized?
Answer
![1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1)](https://static.chemtradehub.com/structs/542/54240-36-7-06e4.webp "1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1)")
This compound is synthesized through a multi-step process involving alkylation of a trichloromethyl benzene derivative, followed by amino substitution and hydrochloric acid derivatization. Common catalysts include palladium-based catalysts, and the overall yield is typically around 70-80%. The reaction conditions include controlled temperature and pressure to ensure high selectivity and yield.
About
CAS No
54240-36-7
English Name
1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1)
Molecular Formula
C13H19Cl2F3N2O
Molecular Weight
347.21 g/mol
SMILES
CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)C(F)(F)F)O.Cl
InChIKey
MMCDXJOMPMIKGP-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15
![1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1) — Shanghai Jixiang Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce6f4d2b2de6e8e95a45bf/67ce6f4d2b2de6e8e95a45bf-logo.webp){kind=logo}
![1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1) — Shanghai Yuyeh Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce9f132b2de6e8e95a48fe/67ce9f132b2de6e8e95a48fe-logo.webp){kind=logo}
![1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1) — HePeng （ ShangHai ） Biotechnology Co Ltd](https://static.chemtradehub.com/suppliers/67ceccf22b2de6e8e95a5e0f/67ceccf22b2de6e8e95a5e0f-logo.webp){kind=logo}