Compound Q&A

How is 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (CAS: 54240-36-7) typically synthesized?

Answer

1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1)
This compound is synthesized through a multi-step process involving alkylation of a trichloromethyl benzene derivative, followed by amino substitution and hydrochloric acid derivatization. Common catalysts include palladium-based catalysts, and the overall yield is typically around 70-80%. The reaction conditions include controlled temperature and pressure to ensure high selectivity and yield.

About

CAS No 54240-36-7
English Name 1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1)
Molecular Formula C13H19Cl2F3N2O
Molecular Weight 347.2079999999999 g/mol
SMILES CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)C(F)(F)F)O.Cl
InChIKey MMCDXJOMPMIKGP-UHFFFAOYSA-N
Last Updated: 2025-10-28 15:15

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