How is 4-(4-Fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide (CAS: 817194-38-0) typically synthesized?

This compound is typically synthesized via a multi-step process involving condensation reactions, amidation, and electrophilic aromatic substitution. Common starting materials include 4-fluoroaniline and 1H-indazole, with acetic anhydride as a key intermediate. The synthesis involves careful optimization of conditions to achieve high yield and selectivity, often employing catalysts such as Lewis acids or transition metal complexes.