Compound Q&A

How is 5-(Dimethylamino)-1-naphthalenesulfonic acid (CAS: 4272-77-9) typically synthesized?

Answer

5-(Dimethylamino)-1-naphthalenesulfonic acid
5-(Dimethylamino)-1-naphthalenesulfonic acid can be synthesized by reacting 1-naphthol with dimethylamine followed by sulfonation. Commonly, sulfuric acid is used as the sulfonating agent, and the reaction is carried out under acidic conditions. The yield is typically around 90%, and the product is purified by recrystallization.

About

CAS No 4272-77-9
English Name 5-(Dimethylamino)-1-naphthalenesulfonic acid
Molecular Formula C12H13NO3S
Molecular Weight 251.31 g/mol
SMILES CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)O
InChIKey BBEQQKBWUHCIOU-UHFFFAOYSA-N
Last Updated: 2025-10-28 10:54

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