Compound Q&A
How is 3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (CAS: 624741-47-5) typically synthesized?
Answer
3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is typically synthesized via Suzuki-Miyaura coupling reactions. The synthesis involves the reaction of 3-fluorophenylboronic acid with 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile in the presence of a palladium catalyst and a base. Commonly used catalysts include Pd(PPh3)4 and PdCl2(dppf), yielding the target compound with moderate to high selectivity.
About
CAS No
624741-47-5
English Name
3-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
Molecular Formula
C13H15BFNO2
Molecular Weight
17.03 g/mol
SMILES
B1(OC(C(O1)(C)C)(C)C)C2=C(C=CC=C2F)C#N
InChIKey
HIMZNJDDVIROEC-UHFFFAOYSA-N
Last Updated: 2025-10-26 09:38
