Compound Q&A
How is 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine (CAS: 944401-75-6) typically synthesized?
Answer
This compound is typically synthesized via a palladium-catalyzed coupling reaction between a fluoro-pyridinamine and a boronic acid derivative. The reaction is carried out in the presence of a base such as sodium carbonate and a palladium(II) acetate catalyst. The yield is usually around 70-80%, with high regioselectivity and good purity.
About
CAS No
944401-75-6
English Name
3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine
Molecular Formula
C11H16BFN2O2
Molecular Weight
238.07 g/mol
SMILES
B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(N=C2)N)F
InChIKey
OAEDVIUUNHFXLJ-UHFFFAOYSA-N
Last Updated: 2025-10-26 09:38
