Compound Q&A

How is 3-(Trifluoromethyl)thiophenol (CAS: 937-00-8) typically synthesized?

Answer

3-(Trifluoromethyl)thiophenol
3-(Trifluoromethyl)thiophenol can be synthesized through various routes, commonly involving the bromination of thiophenol followed by nucleophilic substitution with trifluoromethyl sulfide. This process requires strict control of reaction conditions to achieve high selectivity and yield. Specific catalysts such as sodium hydride or potassium tert-butoxide have been used to enhance the reaction’s efficiency and product purity.

About

CAS No 937-00-8
English Name 3-(Trifluoromethyl)thiophenol
Molecular Formula C7H5F3S
Molecular Weight 178.18 g/mol
SMILES C1=CC(=CC(=C1)S)C(F)(F)F
InChIKey SCURCOWZQJIUGR-UHFFFAOYSA-N
Last Updated: 2025-10-26 09:38

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