Compound Q&A

Are there alternatives to Trifluoromethyl trifluoromethanesulfonate (CAS: 3582-05-6) in synthesis?

Answer

Trifluoromethyl trifluoromethanesulfonate
While Trifluoromethyl trifluoromethanesulfonate (CAS: 3582-05-6) is a powerful reagent, alternatives like trifluoromethyl trifluoromethanesulfonate esters or other strong Lewis acids can be used in its place. Other substitutes include highly fluorinated compounds such as trifluoromethyl trifluoromethanesulfonylimides, which offer similar reactivity with fewer handling and disposal challenges.

About

CAS No 3582-05-6
English Name Trifluoromethyl trifluoromethanesulfonate
Molecular Formula C2F6O3S
Molecular Weight 218.07 g/mol
SMILES C(OS(=O)(=O)C(F)(F)F)(F)(F)F
InChIKey GVZFDPPAJXHNGL-UHFFFAOYSA-N
Last Updated: 2025-10-23 12:19

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