How is (2S)-1-{[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy}-3-phenyl-2-propanamine (CAS: 552325-73-2) typically synthesized?

The compound (2S)-1-{[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy}-3-phenyl-2-propanamine can be synthesized via a multistep process involving the reaction of a pyridine derivative with an indazole derivative in the presence of a base such as sodium hydride. The key steps include alkylation and condensation reactions, yielding the target compound with good selectivity and yield. The synthesis typically involves the use of organic solvents like dimethylformamide (DMF) and requires careful handling to achieve the desired product.