Compound Q&A
How is (s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide (CAS: 88929-35-5) typically synthesized?
Answer
(s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide can be synthesized via the condensation of 4-hydroxy-2-oxopyrrolidone with acetic anhydride in the presence of a catalytic amount of a Lewis acid such as aluminum chloride. The reaction typically affords a 70-80% yield with good stereochemical control, leading to the (s) enantiomer.
About
CAS No
88929-35-5
English Name
(s)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide
Molecular Formula
C6H10N2O3
Molecular Weight
158.16 g/mol
SMILES
C1C(CN(C1=O)CC(=O)N)O
InChIKey
IHLAQQPQKRMGSS-BYPYZUCNSA-N
Last Updated: 2025-10-23 07:31
