Compound Q&A

How is 1-(4-Chloro-3-fluorophenyl)methanamine (CAS: 72235-58-6) typically synthesized?

Answer

1-(4-Chloro-3-fluorophenyl)methanamine
1-(4-Chloro-3-fluorophenyl)methanamine is typically synthesized via a multi-step process involving the protection of an amine, formation of an intermediate, and subsequent deprotection. Common synthetic routes include the use of protecting groups such as tert-butyldimethylsilyl (TBS) group, followed by hydrolysis to obtain the target amine. The overall yield is around 70-80%, with good selectivity and purity achievable under proper conditions.

About

CAS No 72235-58-6
English Name 1-(4-Chloro-3-fluorophenyl)methanamine
Molecular Formula C7H7ClFN
Molecular Weight 159.59 g/mol
SMILES C1=CC(=C(C=C1CN)F)Cl
InChIKey HSNPBYKCCNMQNA-UHFFFAOYSA-N
Last Updated: 2025-10-22 19:24

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