Compound Q&A

How is 1-(3-Bromo-4-methoxyphenyl)ethanone (CAS: 35310-75-9) typically synthesized?

Answer

1-(3-Bromo-4-methoxyphenyl)ethanone
1-(3-Bromo-4-methoxyphenyl)ethanone (CAS: 35310-75-9) is typically synthesized through the reaction of 4-methoxyphenylacetic acid with bromine in the presence of a Lewis acid catalyst such as aluminum bromide. The reaction involves bromination of the phenyl ring followed by elimination to form the ketone. The yield is generally good, around 80-90%, and the reaction is selective towards the bromination of the meta-position.

About

CAS No 35310-75-9
English Name 1-(3-Bromo-4-methoxyphenyl)ethanone
Molecular Formula C9H9BrO2
Molecular Weight 229.07 g/mol
SMILES CC(=O)C1=CC(=C(C=C1)OC)Br
InChIKey JYPGOBDETCKKKV-UHFFFAOYSA-N
Last Updated: 2025-10-22 19:24

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