How is (3R)-3-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 186132-96-7) typically synthesized?

(3R)-3-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline can be synthesized via a multi-step process involving a protected L-proline intermediate, followed by the introduction of the hydroxy and carbonyl groups using appropriate reagents. The synthesis typically requires the use of protecting groups, such as tert-butyldimethylsilyl (TBS) or tert-butyloxycarbonyl (Boc), and various catalysts to control the regioselectivity and stereoselectivity of the reaction.