How is Methyl 2-(3-{3-[(E)-2-(7-chloro-2-quinolinyl)vinyl]phenyl}-3-oxopropyl)benzoate (CAS: 149968-11-6) typically synthesized?

Methyl 2-(3-{3-[(E)-2-(7-chloro-2-quinolinyl)vinyl]phenyl}-3-oxopropyl)benzoate (CAS: 149968-11-6) is synthesized by reacting 2-(7-chloro-2-quinolinyl)vinyl chloride with phenylacetyl chloride, followed by esterification with methyl alcohol. The reaction is typically conducted under mild conditions using a catalytic amount of a Lewis acid such as aluminum chloride to enhance the electrophilic reactivity of the vinyl chloride and acetyl chloride.