Compound Q&A
How is 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (CAS: 1003298-73-4) typically synthesized?
Answer
2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is synthesized via a coupling reaction of the corresponding haloarene with an aryl boronic acid in the presence of a palladium catalyst and a base. Commonly used catalysts include Pd(PPh3)4 and PdCl2(dppf), with an overall yield of around 75-85%. The reaction typically involves B2pin2 as the boronic acid source.
About
CAS No
1003298-73-4
English Name
2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
Molecular Formula
C13H14BF2NO2
Molecular Weight
265.06 g/mol
SMILES
B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(C(=C2)F)C#N)F
InChIKey
XYMVJTWEERDWFY-UHFFFAOYSA-N
Last Updated: 2025-10-22 19:24
