How is [(3S)-4-Benzyl-3-morpholinyl]methanol (CAS: 101376-25-4) typically synthesized?

[(3S)-4-Benzyl-3-morpholinyl]methanol can be synthesized via the Mannich reaction of morpholine, formaldehyde, and benzyl chloride, followed by hydrogenation to reduce the imine to an alcohol. The reaction is catalyzed by palladium on carbon and proceeds with high yield and good selectivity. Post-synthesis purification involves recrystallization from ethanol and filtration to obtain the pure compound.