Compound Q&A

How is 2-Ethoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (CAS: 68527-76-4) typically synthesized?

Answer

2-Ethoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol
2-Ethoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol is synthesized via the reaction of 4-hydroxy-2-methyl-1,3-dioxolan-2-yl phenol with ethyl bromide in the presence of a base such as sodium hydroxide. The reaction proceeds through an elimination mechanism followed by an SN2 substitution. The yield is typically around 75-85%, and the reaction is performed in an aprotic solvent like THF at room temperature.

About

CAS No 68527-76-4
English Name 2-Ethoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol
Molecular Formula C12H16O4
Molecular Weight 224.26 g/mol
SMILES CCOc1cc(ccc1O)C1OCC(O1)C
InChIKey IFUIILQWHYHIEK-UHFFFAOYSA-N
Last Updated: 2025-10-22 12:37

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