Compound Q&A
How is 3-Methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide hydrochloride (CAS: 1448189-80-7) typically synthesized?
Answer
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The compound is synthesized through a multi-step process involving peptide coupling and amidation reactions. Commonly, it is prepared from 3-methyl-L-valine, (4R)-4-hydroxy-L-proline, and 4-(4-methyl-1,3-thiazol-5-yl)benzyl chloride. The synthesis involves careful control of reaction conditions to achieve high yield and selectivity, often using appropriate solvents and catalysts.
About
CAS No
1448189-80-7
English Name
3-Methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide hydrochloride (1:1)
Molecular Formula
C22H31ClN4O3S
Molecular Weight
467.04 g/mol
SMILES
Cl.Cc1ncsc1c2ccc(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](N)C(C)(C)C)cc2
InChIKey
JYRTWGCWUBURGU-MSSRUXLCSA-N
Last Updated: 2025-10-20 00:35
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