How is 3-(2-Cyano-2-propanyl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydro-6-quinazolinyl)amino]phenyl}benzamide (CAS: 878739-06-1) typically synthesized?

3-(2-Cyano-2-propanyl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydro-6-quinazolinyl)amino]phenyl}benzamide is synthesized through multi-step reactions involving the condensation of anhydride with a substituted aromatic amine, followed by coupling with a quinazolinone derivative. The reaction is typically conducted under an inert atmosphere, and the yield can be improved by using anhydrous solvents and appropriate catalysts. High selectivity and yield are achieved by optimizing reaction conditions.