Compound Q&A
How is 2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide (CAS: 439239-90-4) typically synthesized?
Answer
![2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide](https://static.chemtradehub.com/structs/439/439239-90-4-6b9d.webp "2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide")
2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide (CAS: 439239-90-4) is synthesized via a multistep process involving coupling of 2,4,6-trifluorobenzamide with 6-(1-methyl-4-piperidinyl)pyridine-3-carbonyl chloride. The reaction typically requires the use of a coupling agent like HATU and a base such as DIPEA. The yield is around 70-80%, and the selectivity is good, with minimal side products.
About
CAS No
439239-90-4
English Name
2,4,6-Trifluoro-N-{6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl}benzamide
Molecular Formula
C19H18F3N3O2
Molecular Weight
377.37 g/mol
SMILES
CN1CCC(CC1)C(=O)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2
InChIKey
XEDHVZKDSYZQBF-UHFFFAOYSA-N
Last Updated: 2025-10-20 00:35
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