Compound Q&A
How is (1S)-2-Chloro-1-phenylethanol (CAS: 70111-05-6) typically synthesized?
Answer
(1S)-2-Chloro-1-phenylethanol can be synthesized through the chlorination of phenethyl alcohol using thionyl chloride in the presence of a base. The reaction is typically conducted under anhydrous conditions to avoid hydrolysis. The yield is usually around 75-85%, and the selectivity for the (1S) enantiomer is moderate, requiring further purification for high-enantiomeric-purity products.
About
CAS No
70111-05-6
English Name
(1S)-2-Chloro-1-phenylethanol
Molecular Formula
C8H9ClO
Molecular Weight
156.61 g/mol
SMILES
C1=CC=C(C=C1)C(CCl)O
InChIKey
XWCQSILTDPAWDP-MRVPVSSYSA-N
Last Updated: 2025-10-20 00:35
