Compound Q&A
How is [3-Fluoro-4-(trifluoromethyl)phenyl]boronic acid (CAS: 864759-68-2) typically synthesized?
Answer
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[3-Fluoro-4-(trifluoromethyl)phenyl]boronic acid is usually prepared via the Suzuki coupling reaction. The synthesis typically involves the reaction of 3-fluoro-4-(trifluoromethyl)phenyllithium with bis(pinacolato)diboron in the presence of a palladium catalyst, such as Pd(PPh3)4, and an additive like potassium acetate. The yield is generally high, and the reaction is selective and efficient.
About
CAS No
864759-68-2
English Name
[3-Fluoro-4-(trifluoromethyl)phenyl]boronic acid
Molecular Formula
C7H5BF4O2
Molecular Weight
207.91899999999998 g/mol
SMILES
B(c1ccc(c(c1)F)C(F)(F)F)(O)O
InChIKey
OPDBJTGUPJBGII-UHFFFAOYSA-N
Last Updated: 2025-10-20 00:35
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