Compound Q&A

How is Ethyl 4-methyl-1,2,3-thiadiazole-5-carboxylate (CAS: 18212-20-9) typically synthesized?

Answer

Ethyl 4-methyl-1,2,3-thiadiazole-5-carboxylate
Ethyl 4-methyl-1,2,3-thiadiazole-5-carboxylate (CAS: 18212-20-9) is typically synthesized by the reaction of ethyl isothiocyanate with 4-methyl-1,2,3-thiadiazole-5-carbonitrile. The reaction is usually carried out in the presence of a base such as sodium carbonate, and the product is isolated by recrystallization. The yield is generally around 75-85%, and the reaction is highly selective and efficient.

About

CAS No 18212-20-9
English Name Ethyl 4-methyl-1,2,3-thiadiazole-5-carboxylate
Molecular Formula C6H8N2O2S
Molecular Weight 172.21 g/mol
SMILES CCOC(=O)C1=C(N=NS1)C
InChIKey AHPXTXGCMLOXGA-UHFFFAOYSA-N
Last Updated: 2025-10-20 00:35

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