Compound Q&A
How is Bromfenac sodium hydrate (CAS: 120638-55-3) typically synthesized?
Answer
Bromfenac sodium hydrate is typically synthesized by reacting bromfenac, a 1,2-benzothiazine-3-carboxylic acid derivative, with sodium hydroxide in a suitable solvent. The reaction involves esterification followed by base hydrolysis to obtain the sodium salt. Common synthetic methods include phase transfer catalysis and use of organic bases to improve selectivity and yield.
About
CAS No
120638-55-3
English Name
Bromfenac sodium hydrate
Molecular Formula
C30H28Br2N2Na2O9
Molecular Weight
766.3 g/mol
SMILES
C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)[O-].C1=CC(=C(C(=C1)C(=O)C2=CC=C(C=C2)Br)N)CC(=O)[O-].O.O.O.[Na+].[Na+]
InChIKey
PPOSVVJOVKVBPW-UHFFFAOYSA-L
Last Updated: 2025-10-19 20:30
