Compound Q&A
How is 2-Chloro-6-(trifluoromethyl)-1H-benzimidazole (CAS: 86604-86-6) typically synthesized?
Answer
2-Chloro-6-(trifluoromethyl)-1H-benzimidazole is typically synthesized via substitution reactions. One common method involves the nucleophilic substitution of 2-chloro-6-bromomethylbenzimidazole with trifluoromethyl magnesium bromide in a suitable solvent like THF under an inert atmosphere. The yield is generally high, around 80-90%, with good selectivity.
About
CAS No
86604-86-6
English Name
2-Chloro-6-(trifluoromethyl)-1H-benzimidazole
Molecular Formula
C8H4ClF3N2
Molecular Weight
220.58100000000002 g/mol
SMILES
C1=CC2=C(C=C1C(F)(F)F)[NH]C(=N2)Cl
InChIKey
CZQXWSPZVZKNRM-UHFFFAOYSA-N
Last Updated: 2025-10-19 20:30
