How is (2R)-1,1,1-Trifluoro-2-propanamine hydrochloride (CAS: 177469-12-4) typically synthesized?

(2R)-1,1,1-Trifluoro-2-propanamine hydrochloride (CAS: 177469-12-4) is typically synthesized by first preparing the amine and then reacting it with trifluoroacetic acid to form the hydrochloride salt. Common methods include direct acidification of the amine with hydrochloric acid or using trifluoroacetic anhydride with the amine. The yield and selectivity are generally good, with purification typically achieved by recrystallization from appropriate solvents.