How is Sodium 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonate (CAS: 103404-87-1) typically synthesized?

Sodium 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonate is typically synthesized by reacting ethanesulfonic acid with 4-(2-hydroxyethyl)-1-piperazine in the presence of a base, such as sodium hydroxide. The reaction yields a high purity product with good selectivity. The process is carried out at room temperature, and the yield is usually around 85-90%.