Compound Q&A
How is trans-3-(Trifluoromethoxy)cinnamic Acid (CAS: 168833-80-5) typically synthesized?
Answer
Trans-3-(Trifluoromethoxy)cinnamic Acid can be synthesized through a series of reactions including the formation of a trifluoromethoxy group followed by coupling with cinnamic acid. Common methods involve using trifluoromethoxychloride and an amine in the presence of a base, followed by an acylation step. This process yields a high purity product with good selectivity and a yield of around 75-85%.
About
CAS No
168833-80-5
English Name
trans-3-(Trifluoromethoxy)cinnamic Acid
Molecular Formula
C10H7F3O3
Molecular Weight
232.16 g/mol
SMILES
C1=CC(=CC(=C1)OC(F)(F)F)C=CC(=O)O
InChIKey
CLKZZEYGXRWYNI-UHFFFAOYSA-N
Last Updated: 2025-10-19 13:36
