Are there alternatives to Ethyl 3-bromoisonicotinate (CAS: 13959-01-8) in synthesis?

Several alternatives to Ethyl 3-bromoisonicotinate (CAS: 13959-01-8) exist in synthesis. For instance, using other isosteres such as ethyl 2-bromoisonicotinate or ethyl 3-chlorisonicotinate can be considered. Additionally, alternative reagents like bromoacetic acid or chloroacetic acid can serve as starting materials for similar reactions. It is important to evaluate the cost, availability, and reactivity of these alternatives for optimal synthesis.