Compound Q&A
How is Atazanavir EP Impurity J (CAS: 198904-86-8) typically synthesized?
Answer
Atazanavir EP Impurity J is synthesized through a multi-step process starting from t-butyl ethers, involving acid-catalyzed rearrangement and amidation reactions. The synthesis yields moderate to high purity products with excellent selectivity. Common catalysts include sulfuric acid, and the overall yield can reach up to 85%.
About
CAS No
198904-86-8
English Name
Atazanavir EP Impurity J (Atazanavir Di-tert-butyl Analog)
Molecular Formula
C32H42N4O5
Molecular Weight
562.7 g/mol
SMILES
O=C(OC(C)(C)C)NN(C[C@@H]([C@@H](NC(=O)OC(C)(C)C)Cc1ccccc1)O)Cc1ccc(cc1)c1ccccn1
InChIKey
KYSDBVSJLBOZDZ-NSOVKSMOSA-N
Last Updated: 2025-10-17 07:35
