Compound Q&A
How is 4-Chloro-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}aniline (CAS: 87170-48-7) typically synthesized?
Answer
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4-Chloro-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}aniline is typically synthesized via a multi-step process involving the coupling of 3-chloro-5-(trifluoromethyl)pyridine with 4-chloro-3-hydroxyaniline. The reaction uses a palladium catalyst in the presence of a base. The yield is around 70-75%, with high selectivity towards the desired product. This synthesis requires controlled conditions and proper handling of reagents.
About
CAS No
87170-48-7
English Name
4-Chloro-3-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}aniline
Molecular Formula
C12H7Cl2F3N2O
Molecular Weight
323.1 g/mol
SMILES
NC1=CC(OC2=NC=C(C=C2Cl)C(F)(F)F)=C(Cl)C=C1
InChIKey
NMLZNVAMLNUCOY-UHFFFAOYSA-N
Last Updated: 2025-10-17 07:35
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