Compound Q&A
How is (-)-1,2-Bis((2R,5R)-2,5-diphenylphospholano)ethane (CAS: 528565-79-9) typically synthesized?
Answer
(-)-1,2-Bis((2R,5R)-2,5-diphenylphospholano)ethane is typically synthesized via a Wittig-type reaction, where the 1,2-diphenylphospholane is reacted with a suitable aldehyde or ketone in the presence of a strong base like sodium hydride. The reaction yields the compound in good yield with high stereoselectivity, and the use of chiral auxiliaries can further enhance the stereoselectivity. The reaction is typically carried out in an inert solvent like dichloromethane under anhydrous conditions.
About
CAS No
528565-79-9
English Name
(-)-1,2-Bis((2R,5R)-2,5-diphenylphospholano)ethane
Molecular Formula
C34H36P2
Molecular Weight
506.61 g/mol
SMILES
C1CC(P(C1C2=CC=CC=C2)CCP3C(CCC3C4=CC=CC=C4)C5=CC=CC=C5)C6=CC=CC=C6
InChIKey
VHHAZLMVLLIMHT-YFRBGRBWSA-N
Last Updated: 2025-10-17 07:35
