Compound Q&A

How is ((2R,3R)-3-(benzoyloxy)-4,4-difluoro-5-hydroxytetrahydrofuran-2-yl)methyl benzoate (CAS: 1173824-58-2) typically synthesized?

Answer

((2R,3R)-3-(benzoyloxy)-4,4-difluoro-5-hydroxytetrahydrofuran-2-yl)methyl benzoate
((2R,3R)-3-(Benzoyloxy)-4,4-difluoro-5-hydroxytetrahydrofuran-2-yl)methyl benzoate is typically synthesized through a multi-step process involving the protection of a hydroxy group, followed by the introduction of a benzoyloxy group and subsequent fluorination. Common catalysts include aluminum chloride and trifluoromethanesulfonic acid, with a yield of around 70%. The reaction conditions are carefully controlled to ensure high selectivity and purity.

About

English Name ((2R,3R)-3-(benzoyloxy)-4,4-difluoro-5-hydroxytetrahydrofuran-2-yl)methyl benzoate
Molecular Formula C19H16F2O6
Molecular Weight 378.32 g/mol
SMILES C1=CC=C(C=C1)C(=O)OCC2C(C(C(O2)O)(F)F)OC(=O)C3=CC=CC=C3
InChIKey PRZDMMRKPZAYHW-QOYAAKSSSA-N
Last Updated: 2025-10-17 07:35

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