Compound Q&A
How is 1-Chloro-2-fluoro-4-methylbenzene (CAS: 5527-94-6) typically synthesized?
Answer
1-Chloro-2-fluoro-4-methylbenzene (CAS: 5527-94-6) is typically synthesized via a Friedel-Crafts alkylation of 2-fluoro-4-methylbenzene with chlorine gas in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction is carried out under anhydrous conditions to avoid side reactions. The yield and selectivity of the reaction are influenced by the purity of reactants and the reaction conditions.
About
CAS No
5527-94-6
English Name
1-Chloro-2-fluoro-4-methylbenzene
Molecular Formula
C7H6ClF
Molecular Weight
144.58 g/mol
SMILES
CC1=CC(=C(C=C1)Cl)F
InChIKey
MHXNHUSVBYUTJL-UHFFFAOYSA-N
Last Updated: 2025-10-17 07:35
