Compound Q&A
How is 3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine (CAS: 1229236-86-5) typically synthesized?
Answer
![3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine](https://static.chemtradehub.com/structs/122/1229236-86-5-365e.webp "3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine")
The compound is synthesized via a multi-step process involving the functionalization of a benzyl chloride, followed by coupling reactions with a pyrazole derivative and morpholine. Commonly used catalysts include Pd(PPh3)4 and HATU. The overall yield is around 50-60%, with high selectivity for the desired product.
About
CAS No
1229236-86-5
English Name
3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine
Molecular Formula
C23H25ClFN7O
Molecular Weight
469.95 g/mol
SMILES
Cc1cc(n[nH]1)Nc2cc(c3nc(c(n3n2)Cc4ccc(cc4F)Cl)C)CN5CCOCC5
InChIKey
SQSZANZGUXWJEA-UHFFFAOYSA-N
Last Updated: 2025-10-16 16:48
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